ASTM D6259-23 - Standard Practice for Determination of a Pooled Limit of Quantitation for a Test Method

1.1 This practice covers the use of standard regression techniques and data from an interlaboratory study to determine a lower quantitative limit for a test method. This determined lower limit represents the numerical limit at or above which the test results are considered to be quantitatively meaningful for commerce or regulatory activities by this practice. It is defined by this standard as the pooled limit of quantitation (PLOQ) for the test method.

1.2 This practice is applicable to test methods that are capable of producing numerical test results close to zero. Examples are those test methods that determine quantitatively the concentration of analyte(s) near zero.

1.3 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.