ASTM E1687-25
Standard Test Method for Determining Carcinogenic Potential of Virgin Base Oils in Metalworking Fluids
| Standard number: | ASTM E1687-25 |
| Released: | 01.04.2025 |
| Status: | Active |
| Pages: | 16 |
| Section: | 11.03 |
| Keywords: | base oils; dermal carcinogenicity; modified Ames test; mutagenicity; |
1.1 This test method covers a microbiological test procedure based upon the Salmonella mutagenesis assay of Ames et al. (1)2 (see also Maron et al. (2)).
1.1.1 Blackburn et al. (3, 4) demonstrated that the results of this test method are strongly predictive of oil dermal carcinogenicity. Therefore, this test method can be used as a screening technique to detect the presence of potential dermal carcinogens in virgin base oils used in the formulation of metalworking oils.
1.1.2 Persons who perform this test should be well versed in the conduct of the Ames test and conversant with the physical and chemical properties of petroleum products.
1.2 The test method is not recommended as the sole testing procedure for oils which have viscosities less than 18 cSt (90 SUS) at 40 °C, or for formulated metalworking fluids.
1.3 The values stated in SI units are to be regarded as the standard. The values given in parentheses are provided for information only.
1.4 This test method requires the housing and handling of live animals; in most regions there are regulations pertaining to laboratory animal handling. This method does not address the specifics of animal husbandry associated with the test method. Laboratories performing the test methods are expected to comply with the relevant local regulations, including licenses and permits required to maintain laboratory animals.
1.5 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use. Section 9 provides general guidelines for safe conduct of this test method.
1.6 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.