BS ISO 19290:2021 - Cigarettes: Determination of Tobacco Specific Nitrosamines in Mainstream Cigarette Smoke

Standard Number: BS ISO 19290:2021

Pages: 22

Released: February 24, 2021

ISBN: 978 0 539 15285 2

Status: Standard

Overview

The BS ISO 19290:2021 standard is an essential document for professionals in the tobacco industry, researchers, and regulatory bodies. It provides a comprehensive method for the determination of tobacco-specific nitrosamines (TSNAs) in mainstream cigarette smoke using the advanced technique of Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). This standard is crucial for ensuring the safety and quality of cigarette products by accurately measuring the levels of harmful nitrosamines, which are known carcinogens.

Why is this Standard Important?

Tobacco-specific nitrosamines are among the most potent carcinogens found in tobacco smoke. Their presence in mainstream cigarette smoke poses significant health risks to smokers and those exposed to secondhand smoke. The BS ISO 19290:2021 standard provides a scientifically validated method to quantify these compounds, enabling manufacturers to monitor and control their levels in cigarette products. This is vital for compliance with health regulations and for the protection of public health.

Key Features of the Standard

• Comprehensive Methodology: The standard outlines a detailed procedure for the extraction and analysis of TSNAs using LC-MS/MS, ensuring accurate and reproducible results.
• Advanced Analytical Technique: LC-MS/MS is a state-of-the-art analytical technique that combines the separation capabilities of liquid chromatography with the detection power of mass spectrometry, providing high sensitivity and specificity for TSNA detection.
• Quality Assurance: The standard includes guidelines for quality control and validation of the analytical method, ensuring the reliability of the results.
• Regulatory Compliance: Adhering to this standard helps manufacturers meet regulatory requirements and demonstrate their commitment to product safety and quality.

Who Should Use This Standard?

This standard is designed for a wide range of stakeholders in the tobacco industry, including:

• Tobacco Manufacturers: To ensure their products meet safety standards and regulatory requirements.
• Quality Control Laboratories: For accurate testing and monitoring of TSNA levels in cigarette smoke.
• Regulatory Bodies: To establish and enforce safety standards for tobacco products.
• Research Institutions: For conducting studies on the health impacts of tobacco-specific nitrosamines.

Benefits of Using BS ISO 19290:2021

Implementing the BS ISO 19290:2021 standard offers numerous benefits, including:

• Enhanced Product Safety: By accurately measuring and controlling TSNA levels, manufacturers can reduce the health risks associated with their products.
• Improved Consumer Confidence: Compliance with recognized standards demonstrates a commitment to quality and safety, enhancing brand reputation and consumer trust.
• Competitive Advantage: Companies that adhere to international standards are better positioned in the global market, as they meet the expectations of regulators and consumers worldwide.
• Scientific Credibility: The use of a validated and standardized method ensures the credibility and reliability of research findings related to tobacco smoke analysis.

Conclusion

The BS ISO 19290:2021 standard is an indispensable tool for anyone involved in the production, regulation, or study of tobacco products. By providing a robust and reliable method for the determination of tobacco-specific nitrosamines in cigarette smoke, it plays a critical role in safeguarding public health and ensuring the quality of tobacco products. Whether you are a manufacturer, a quality control specialist, a regulator, or a researcher, this standard is essential for your work in the tobacco industry.

BS ISO 19290:2021

This standard BS ISO 19290:2021 Cigarettes. Determination of tobacco specific nitrosamines in mainstream cigarette smoke.Method using LC-MS/MS is classified in these ICS categories:

• 65.160 Tobacco, tobacco products and related equipment

This document specifies a method for the quantification of four tobacco specific nitrosamines (TSNAs) in the total particulate matter of mainstream cigarette smoke by using reversed phase high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS). The quantified TSNAs are: N-nitrosonornicotine (NNN), N-nitrosoanatabine (NAT), N-nitrosoanabasine (NAB) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).