BS ISO 21501-3:2019 - Determination of Particle Size Distribution

Welcome to the world of precision and accuracy with the BS ISO 21501-3:2019 standard. This comprehensive document is your ultimate guide to understanding and implementing the determination of particle size distribution using single particle light interaction methods, specifically focusing on light extinction liquid-borne particle counters.

Overview

The BS ISO 21501-3:2019 standard is a crucial resource for professionals in industries where particle size distribution is a critical parameter. Released on December 4, 2019, this standard provides detailed methodologies and guidelines to ensure accurate and reliable measurements of particle sizes in various liquid mediums. With a total of 28 pages, it offers an in-depth exploration of the principles and applications of light extinction techniques in particle counting.

Key Features

• Standard Number: BS ISO 21501-3:2019
• Pages: 28
• Release Date: December 4, 2019
• ISBN: 978 0 539 02808 9
• Status: Standard

Why Choose BS ISO 21501-3:2019?

This standard is essential for ensuring the quality and consistency of particle size measurements in various industries, including pharmaceuticals, environmental monitoring, and manufacturing. By adhering to the guidelines set forth in this document, you can achieve:

• Enhanced Accuracy: The standard provides precise methodologies for measuring particle sizes, reducing the margin of error and increasing the reliability of your results.
• Consistency Across Measurements: By following a standardized approach, you ensure that your measurements are consistent and comparable across different samples and conditions.
• Compliance with Industry Standards: Adopting this standard helps you meet industry regulations and quality assurance requirements, enhancing your credibility and reputation.

Applications

The BS ISO 21501-3:2019 standard is applicable in a wide range of fields where particle size distribution is a critical factor. Some of the key applications include:

• Pharmaceutical Industry: Ensuring the quality and efficacy of drug formulations by accurately measuring particle sizes in liquid suspensions.
• Environmental Monitoring: Assessing water quality and pollution levels by analyzing particle sizes in liquid samples.
• Manufacturing: Controlling the quality of products by monitoring particle sizes in various liquid-based processes.

Understanding Light Extinction Methods

The light extinction method is a powerful technique for measuring particle sizes in liquid-borne samples. It involves passing a beam of light through a liquid sample and measuring the reduction in light intensity caused by particles in the path of the beam. This method is highly effective for detecting and sizing particles in a wide range of liquid mediums, providing accurate and reliable results.

Benefits of Light Extinction Particle Counters

Light extinction particle counters offer several advantages, making them a preferred choice for many applications:

• High Sensitivity: Capable of detecting even the smallest particles, ensuring comprehensive analysis of your samples.
• Non-Invasive Measurement: The method does not alter the sample, preserving its integrity for further analysis.
• Rapid Results: Provides quick and efficient measurements, allowing for timely decision-making and process adjustments.

Conclusion

The BS ISO 21501-3:2019 standard is an invaluable resource for professionals seeking to enhance their understanding and implementation of particle size distribution measurements. By adopting this standard, you can ensure the accuracy, consistency, and compliance of your measurements, ultimately improving the quality and reliability of your processes and products.

Whether you are in the pharmaceutical, environmental, or manufacturing industry, this standard provides the tools and knowledge you need to excel in your field. Embrace the precision and reliability of the BS ISO 21501-3:2019 standard and take your particle size distribution measurements to the next level.

BS ISO 21501-3:2019

This standard BS ISO 21501-3:2019 Determination of particle size distribution. Single particle light interaction methods is classified in these ICS categories:

• 19.120 Particle size analysis. Sieving

This document describes a calibration and verification method for a light extinction liquid-borne particle counter (LELPC), which is used to measure the size and particle number concentration of particles suspended in liquid. The light extinction method described in this document is based on single particle measurements. The typical size range of particles measured by this method is between 1 µm and 100 µm in particle size.

The method is applicable to instruments used for the evaluation of the cleanliness of pharmaceutical products (e.g. injections, water for injections, infusions), as well as the measurement of number and size distribution of particles in various liquids.

The following are within the scope of this document:

• size setting error;

• counting efficiency;

• size resolution;

• maximum particle number concentration;

• sampling flow rate error;

• sampling time error;

• sampling volume error;

• calibration interval;

• reporting results from test and calibration.