BS ISO 23921:2020 - Cigarettes: Determination of Tobacco Specific Nitrosamines

Discover the comprehensive standard BS ISO 23921:2020, a pivotal document for professionals in the tobacco industry and researchers focused on the analysis of cigarette smoke. This standard provides a detailed methodology for the determination of tobacco-specific nitrosamines (TSNAs) in mainstream cigarette smoke using an intense smoking regime, employing the advanced technique of Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).

Key Features of BS ISO 23921:2020

• Standard Number: BS ISO 23921:2020
• Pages: 24
• Release Date: October 1, 2020
• ISBN: 978 0 539 04200 9
• Status: Standard

Understanding the Importance of TSNAs Analysis

Tobacco-specific nitrosamines are among the most potent carcinogens found in tobacco products. Their presence in cigarette smoke poses significant health risks to smokers and those exposed to secondhand smoke. The accurate determination of TSNAs is crucial for regulatory compliance, product development, and public health research. The BS ISO 23921:2020 standard provides a robust framework for laboratories and researchers to measure these compounds with precision and reliability.

Advanced Methodology: LC-MS/MS

The method outlined in this standard utilizes Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS), a state-of-the-art analytical technique known for its sensitivity and specificity. This method allows for the detection and quantification of TSNAs at trace levels, ensuring that even the smallest concentrations are accurately measured. The use of an intense smoking regime further enhances the reliability of the results, simulating real-world smoking conditions more closely than traditional methods.

Who Should Use This Standard?

This standard is essential for:

• Tobacco Industry Professionals: Ensuring product safety and compliance with international regulations.
• Research Scientists: Conducting studies on the health impacts of smoking and developing strategies to reduce harmful emissions.
• Regulatory Bodies: Setting and enforcing standards for tobacco product safety.
• Public Health Organizations: Understanding the risks associated with tobacco use and advocating for safer practices.

Comprehensive Coverage in 24 Pages

With its concise yet comprehensive 24-page format, BS ISO 23921:2020 offers a detailed guide that is both accessible and thorough. It covers all necessary aspects of the analytical process, from sample preparation to data interpretation, ensuring that users can implement the method effectively and efficiently.

Why Choose BS ISO 23921:2020?

Choosing this standard means opting for a document that is not only technically rigorous but also aligned with the latest scientific advancements. Released on October 1, 2020, it reflects the most current understanding and practices in the field of tobacco analysis. Its ISBN, 978 0 539 04200 9, ensures easy reference and cataloging for libraries and institutions.

Conclusion

BS ISO 23921:2020 is an indispensable resource for anyone involved in the analysis of cigarette smoke. Its focus on the determination of tobacco-specific nitrosamines using LC-MS/MS under an intense smoking regime makes it a critical tool for ensuring the safety and compliance of tobacco products. By adopting this standard, professionals can contribute to a safer, more informed approach to tobacco product analysis and regulation.

BS ISO 23921:2020

This standard BS ISO 23921:2020 Cigarettes. Determination of tobacco specific nitrosamines in mainstream cigarette smoke with an intense smoking regime. Method using LC-MS/MS is classified in these ICS categories:

• 65.160 Tobacco, tobacco products and related equipment

This document specifies a method for the quantification of four tobacco specific nitrosamines (TSNAs) in the total particulate matter of cigarette mainstream smoke with the intense smoking regime specified in ISO 20778 by using reversed phase high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS). The quantified TSNAs are: N-nitrosonornicotine (NNN), N-nitrosoanatabine (NAT), N-nitrosoanabasine (NAB) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).